Dr. Dan Gaffney

Head of Cellular Genetics

My role is to oversee the analysis and experimental generation of genomics data from cell model systems. This helps us understand how disease variants disrupt normal cellular function, and is a critical step in identifying promising candidate therapeutic targets.

I did my PhD in evolutionary Genetics in the University of Edinburgh, followed by postdocs at the University of McGill and University of Chicago.

I have a mixed computational and wet lab background, and I also run a lab situated at the Wellcome Trust Sanger Institute in Cambridge. In my academic life, my group has published extensively on noncoding regulatory variation. As a Group Leader at the Wellcome Sanger Institute, I manage a group of 13 people dedicated to mapping and characterising the cellular functions of noncoding variation. We specialise in using human induced pluripotent stem cells (IPSCs) as a model system.

I’m proud to have co-led the analysis of the Human Induced Pluripotent Stem Cell Initiative and to be among the first groups to use stem cells at scale to study the functions of common human genetic variation.

In my spare time, I enjoy spending time with my wife and our two boys, running, gardening and cooking.